The 2010 Best Semiprozine Hugo nominees are:
- Ansible edited by David Langford
- Clarkesworld edited by Neil Clarke, Sean Wallace, & Cheryl Morgan
- Interzone edited by Andy Cox
- Locus edited by Charles N. Brown, Kirsten Gong-Wong, & Liza Groen Trombi
- Weird Tales edited by Ann VanderMeer & Stephen H. Segal
There were 377 ballots cast in this category. It placed 6th in the categories with the most ballots behind Novel, Dramatic Long Form, Short Story, Editor Short Form, and Novelette. Semiprozines received more nominations than Novella, Campbell Award, Pro Artist, Fan Writer, Fanzine, Editor Long Form, Dramatic Short, Best Related, Graphic Story and Fan Artist.